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“If we understand how this chromatin state is set up, And exactly how it relates to oocyte excellent, it could finally lead to therapies for many types of infertility,” suggests Namekawa.
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This may aid clarify why more mature Girls usually tend to bear children with chromosomal Issues like Down Syndrome, where an extra copy of chromosome 21 finds its way into an oocyte — and afterwards, an embryo.
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Namekawa believes that in human oocytes, adjustments in these styles could disrupt the delicate choreography of genes remaining turned on and off at the appropriate moments — leaving them unprepared for fertilization or development into balanced embryos. Adjustments in chromatin composition as an oocyte ages may additionally impact the way in which that chromosomes segregate for the duration of mobile division.
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